Biomacromolecular antifreezes distinguish ice from water, function by binding to specific planes of ice, and could have many applications from cryobiology to aerospace where ice is a problem. In biology, antifreeze protein (AFP) activity is regulated by protein expression levels via temperature and light-regulated expression systems, but in the laboratory…
sergio.rodrigues@xenocs.com27 January 2020
A series of polyethylene-like ionomers with periodic sulfonate groups were synthesized by polyesterification of octatetracontane-1,48-diol and tetrabutylammonium dimethyl sulfosuccinate. Optional cation exchange in aqueous dispersions replaced the NBu4+ counterions for Na+ or Cs+. The defined periodic microstructure of the polymers leads to the formation of layered structures in bulk and…
sergio.rodrigues@xenocs.com27 January 2020
We investigate the effect of cellulose nanocrystals (CNC) as a hydrophilic nanoparticle on the characteristics of polyethersulfone (PES) based membranes. The membranes are fabricated using typical nonsolvent induced phase separation (NIPS) method. We study the radius of gyration and aggregation of PES in dimethylformamide in the presence of CNC, the…
sergio.rodrigues@xenocs.com27 January 2020
Depending on the linker length between the V H and the V L domain, single-chain Fv (scFv) antibody fragments form monomers, dimers (diabodies) or higher oligomers. We aimed at generating a diabody of the anti-MET antibody 3H3 to use it as crystallization chaperone to promote crystallization of the MET ectodomain…
sergio.rodrigues@xenocs.com27 January 2020
Microporous ceria thin films having nanocrystallites network were synthesized by evaporation-induced self-assembly process, using P123 amphiphilic copolymer as structure-directing agent. The impact of key experimental parameters, i.e., the sol ageing, the relative humidity (RH), the thermal treatment, on the thin layer elaboration were investigated. The results show that the organization…
sergio.rodrigues@xenocs.com27 January 2020
Mesoporous Silica Nanoparticles (MSN) are used in an increasing number of applications in nanomedicine. Their synthesis and external/internal functionalization have been extensively studied as well as their biological properties. Nevertheless, the conventional drug loading processes of MSN (such as impregnation), do not enable sufficient efficiency and are difficult to consider…
sergio.rodrigues@xenocs.com27 January 2020
Ellipsometry porosimetry provides full adsorption/desorption isotherms and is among the most accurate techniques to probe porosity in thin films. Here we address a novel technique based on desorption scanning for a precise assessment of the porosity features revealing the size distribution of interconnections between the various populations of pores in…
sergio.rodrigues@xenocs.com27 January 2020
Layered RuddlesdenPopper (RP) phase (2D) halide perovskites have attracted tremendous attention due to the wide tunability on their optoelectronic properties and excellent robustness in photovoltaic devices. However, charge extraction/transport and ultimate power conversion efficiency (PCE) in 2D perovskite solar cells (PSCs) are still limited by the non-eliminable quantum well effect.…
sergio.rodrigues@xenocs.com27 January 2020
Hepatitis B virus causes acute and chronic infections in millions of people worldwide and, since 1982, a vaccine with 95% effectiveness has been available for immunization. The main component of the recombinant hepatitis B vaccine is the surface antigen protein (HBsAg). In this work, the effect of pH, ionic strength…
sergio.rodrigues@xenocs.com27 January 2020
The structural evolution of micro-injection molded high density polyethylene (HDPE) at the molecular and lamellar levels was investigated as a function of temperature during heating process using wide angle X-ray diffraction (WAXD) and small angle X-ray scattering (SAXS) techniques. The molded sample exhibits a peculiar multilayer structure of skin and…
sergio.rodrigues@xenocs.com27 January 2020