Optimize protein crystallization conditions. Monitor protein behavior in vitro. Identify systems for drug delivery.
Characterization at the nanoscale can help you find answers.
With X-ray scattering in your lab, you can for example:
- Study the interactions between proteins (higher order structure), including stability and aggregation pathways
- Determine protein size, molecular weight and degree of folding
- Analyze the formation and structure of liquid crystals in lipid drug delivery systems
- Access the structure of intrinsically disordered proteins and RNA and quantify movements of flexible domains
In-lab SEC-SAXS for structural investigation of complex samples
In this application example, SAXS data of sufficiently high quality to extract structural information such as 3D envelopes of small and large protein species are obtained through in-line gel filtration.
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using X-ray scattering for their research in structural biology
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Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences, 2017
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(GI-)SAXS/WAXS/USAXS beamline for the laboratory
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X-ray Scattering Analysis and Calculation Tool.