Drug discovery and formulation

Accelerate your drug discovery process with better insight into protein, antibody or macromolecular complex shape information in solution also for flexible and disordered proteins.

Improve your analysis toolbox for drug formulation with a fingerprint technique, and gain precious development time by getting:

  • Information on protein interactions in both concentrated and diluted solutions with freshly prepared samples
  • High sensitivity for oligomerization
  • Conformational and structural changes information to improve long term stability prediction  

Monitor and compare phase transitions of lipid drug delivery systems in raw materials, extruded liposomes and drug products.

In-lab SEC-SAXS for structural investigation of complex samples

In this application example, SAXS data of sufficiently high quality to extract structural information such as 3D envelopes of small and large protein species are obtained through in-line gel filtration.

High throughput screening of pharmaceutical formulations with SAXS

Protein-Protein interactions, radius of gyration, degree of folding, size and shape can be monitored in high throughput conditions to access structural, conformation and colloidal stability.

In addition, discover how SAXS can contribute to research, development and quality control at the various stages of drug and vaccine development.

Want to learn more on drug development?

SAXS as a tool for characterizing monoclonal antibody-protein antigen interactions

Detailed biophysical description of antibody-protein antigens interactions is important for guiding physical characterization and molecular engineering of therapeutic targets. Proteins can […]


Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing […]


The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such as […]

Thorough investigation of oligomers during protein fibrillation

Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the adverse effects are not mature fibrils, but oligomers. These are aggregates formed transiently at […]

High throughput protein envelope determination

Small-angle X-ray scattering is complementary to other structural biology techniques. It provides reliable information on the shape of proteins in solution and associated parameters including macromolecule interactions and dynamics. Reliability of the measurements and high throughput are […]

Protein structure resolution

The Small-angle X-ray Scattering (SAXS) technique is now well known for studying biological systems and more specifically proteins in solution. SAXS measurements allow the determination of the […]

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using X-ray scattering for their research in structural biology

Customer publications

Discover how scientists use Xenocs instruments for their research & publications

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
Parra-Ortiz, E.; Browning, K.L.; Damgaard, L. S. E.; Nordström, R.; Micciulla, S.; Bucciarelli, S.; Malmsten, M.
Journal of Colloid and Interface Science2019
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences2017


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Protein Structure Analysis

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(GI-)SAXS/WAXS/USAXS beamline for the laboratory


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SAXS Small And Wide Angle X-ray Scattering France


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Protein Structure Analysis

XSACT software

X-ray Scattering Analysis and Calculation Tool.

Protein Structure Analysis