Drug discovery and formulation

Accelerate your drug discovery process with better insight into protein, antibody or macromolecular complex shape information in solution also for flexible and disordered proteins.

Improve your analysis toolbox for drug formulation with a fingerprint technique, and gain precious development time by getting:

  • Information on protein interactions in both concentrated and diluted solutions with freshly prepared samples
  • High sensitivity for oligomerization
  • Conformational and structural changes information to improve long term stability prediction  

Monitor and compare phase transitions of lipid drug delivery systems in raw materials, extruded liposomes and drug products.

In-lab SEC-SAXS for structural investigation of complex samples

In this application example, SAXS data of sufficiently high quality to extract structural information such as 3D envelopes of small and large protein species are obtained through in-line gel filtration.

High throughput screening of pharmaceutical formulations with SAXS

Protein-Protein interactions, radius of gyration, degree of folding, size and shape can be monitored in high throughput conditions to access structural, conformation and colloidal stability.

In addition, discover how SAXS can contribute to research, development and quality control at the various stages of drug and vaccine development.

Some of our customers

using X-ray scattering for their research in structural biology

Publications

Discover how scientists use Xenocs instruments for their research & publications

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
Parra-Ortiz, E.; Browning, K.L.; Damgaard, L. S. E.; Nordström, R.; Micciulla, S.; Bucciarelli, S.; Malmsten, M.
Journal of Colloid and Interface Science2019
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences2017

Products

Discover our products relevant to research in structural biology.

Nano-inXider

Smart nanoscale characterization

Protein Structure Analysis

Xeuss 3.0

The Next Generation

(GI-)SAXS/WAXS/USAXS beamline for the laboratory

BioXolver

Accelerate your biostructural research

SAXS Small And Wide Angle X-ray Scattering France

Services

We are here to help.

Accessories

A wide range of accessories are available for your research.

Protein Structure Analysis

XSACT software

X-ray Scattering Analysis and Calculation Tool.

Protein Structure Analysis