Accelerate your drug discovery process with better insight into protein, antibody or macromolecular complex shape information in solution also for flexible and disordered proteins.
Drug discovery and formulation
Improve your analysis toolbox for drug formulation with a fingerprint technique, and gain precious development time by getting:
- Information on protein interactions in both concentrated and diluted solutions with freshly prepared samples
- High sensitivity for oligomerization
- Conformational and structural changes information to improve long term stability prediction
Monitor and compare phase transitions of lipid drug delivery systems in raw materials, extruded liposomes and drug products.
In-lab SEC-SAXS for structural investigation of complex samples
In this application example, SAXS data of sufficiently high quality to extract structural information such as 3D envelopes of small and large protein species are obtained through in-line gel filtration.
In addition, discover how SAXS can contribute to research, development and quality control at the various stages of drug and vaccine development.
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Detailed biophysical description of antibody-protein antigens interactions is important for guiding physical characterization and molecular engineering of therapeutic targets. Proteins can […]
Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing […]
The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such as […]
Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the adverse effects are not mature fibrils, but oligomers. These are aggregates formed transiently at […]
Small-angle X-ray scattering is complementary to other structural biology techniques. It provides reliable information on the shape of proteins in solution and associated parameters including macromolecule interactions and dynamics. Reliability of the measurements and high throughput are […]
The Small-angle X-ray Scattering (SAXS) technique is now well known for studying biological systems and more specifically proteins in solution. SAXS measurements allow the determination of the […]
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using X-ray scattering for their research in structural biology
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Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences, 2017
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Smart nanoscale characterization
The Next Generation
(GI-)SAXS/WAXS/USAXS beamline for the laboratory
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X-ray Scattering Analysis and Calculation Tool.