SAXS for drug development

Xenocs SAXS Pharma Blog

SAXS continues its fast adoption into industrial drug development in Characterization, Formulation and Quality Control

Welcome to the Xenocs blog for exploring the remarkable potential of Small-Angle X-ray Scattering (SAXS) in the realm of pharmaceuticals.

SAXS, a non-intrusive technique for investigating nanoscale structures, holds transformative implications for drug development and analysis. From deciphering molecular behavior to facilitating protein therapeutics, its diverse applications are reshaping pharmaceutical research.

Gain understanding of how SAXS aids in uncovering drug mechanisms, optimizing delivery systems, and catalyzing breakthroughs in personalized medicine. Start your journey with us to uncover the pivotal role of SAXS in advancing health sciences.

This month focus: Liposome drug carriers

SAXS features on liposome characterization

  • Revealing high degree of details on structure and morphology, size, bilayer thickness of liposomes or LNPs
  • Deducting PEGylation effect, steric and electrostatic effects, liposome-liposome interactions
  • Tracking the location of cholesterol, drug, or other molecules in liposomes
  • Observing phase transition of lipids, lipid polymorphism, lamellarity
  • Monitoring environmental stimulus effect on liposomes: temperature, lipid concentration, salt concentration


Next events

Agenda to come soon.

Previous event

Xenocs and BIOSAXS invite you to join our interactive two-day short course focused on the benefits and use of Small Angle X-ray Scattering (SAXS) for the pharmaceutical industry.

In addition to showcasing the benefits of SAXS at various stages of the drug development & production processes, we will cover practical workflows and how you can characterize and analyse (bio-)therapeutic systems, APIs and drug delivery systems with SAXS in the lab and at synchrotron.

Application notes

Application note – SAXS as a tool to study Lipid Nanoparticles
Application note – Characterization of protein self-association
Application note – Characterization of protein intermolecular interactions
Application note – High throughput protein envelope determination
AN – Protein-protein interactions, from in vivo functionality to pharma…
AN – In-lab SEC-SAXS for structural investigation of complex samples

Curious about your samples? :

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