Category

Particle interactions

ApplicationCharacterizationCustomer publicationsMaterialOil & gasParticle interactionsSAXSSurfactantsTechnique

Enhancing the accessibility to basic sites of as-synthesized silicas applied in catalytic transesterification

Zapelini, Iago W.; Silva, Laura L.; Oliveira, Cristiano L. P.; Cardoso, Dilson

Heterogeneous catalysis for biodiesel production is a current challenge due to the low activity of solid catalysts, especially caused by diffusional resistances. Hybrid silicas, containing SiO?CTA+ provide high conversions in the transesterification of oils and model molecules, but this activity is limited to the external surface area. The generation of…
ApplicationCharacterizationCustomer publicationsMaterialParticle interactionsProteins & DNA/RNASAXSStructural biologyTechnique

Studying Excipient Modulated Physical Stability and Viscosity of Monoclonal Antibody Formulations Using Small-Angle Scattering

Xu, Amy Yuanyuan; Castellanos, Maria Monica; Mattison, Kevin; Krueger, Susan; Curtis, Joseph E.

Excipients are substances that are added to therapeutic products to improve stability, bioavailability, and manufacturability. Undesirable protein-protein interactions (PPI) can lead to self-association and/or high solution viscosity in concentrated protein formulations that are typically greater than 50 mg/mL. Therefore, understanding the effects of excipients on nonspecific PPI is important for…
ApplicationCharacterizationCustomer publicationsMaterialParticle interactionsProteins & DNA/RNASAXSShapeSizeStructural biologyTechnique

Disentangling the role of solvent polarity and protein solvation in folding and self-assembly of ?-lactalbumin

Bucciarelli, Saskia; Sayedi, Edres Sayed; Osella, Silvio; Trzaskowski, Bartosz; Vissing, Karina Juul; Vestergaard, Bente; Foderà, Vito

Protein (mis)folding, stability and aggregation are of interest in numerous fields, such as food sciences, biotechnology, and health sciences, and efforts are directed towards the elucidation of the underlying molecular mechanisms. Through an integrative approach, we show that a subtle balance between hydrogen bond formation and hydrophobic interactions defines protein…
ApplicationCharacterizationCustomer publicationsMaterialParticle interactionsProteins & DNA/RNASAXSStructural biologyTechnique

X-ray Scattering and Coarse-Grained Simulations for Clustering and Interactions of Monoclonal Antibodies at High Concentrations

Dear, Barton J.; Bollinger, Jonathan A.; Chowdhury, Amjad; Hung, Jessica J.; Wilks, Logan R.; Karouta, Carl A.; Ramachandran, Kishan; Shay, Tony Y.; Nieto, Maria P.; Sharma, Ayush; Cheung, Jason K.; Nykypanchuk, Dmytro; Godfrin, P. Douglas; Johnston, Keith P.; Truskett, Thomas M.

Attractive protein–protein interactions (PPI) in concentrated monoclonal antibody (mAb) solutions may lead to reversible oligomers (clusters) that impact colloidal stability and viscosity. Herein, the PPI are tuned for two mAbs via the addition of arginine (Arg), NaCl, or ZnSO4 as characterized by the structure factor (Seff(q)) with small-angle X-ray scattering…
ApplicationCharacterizationCustomer publicationsMaterialOtherParticle interactionsProteins & DNA/RNASAXSSelf-assembled materialShapeSizeStructural biologyTechnique

Twisted Ribbon Aggregates in a Model Peptide System

Rüter, Axel; Kuczera, Stefan; Pochan, Darrin J.; Olsson, Ulf

The model peptides A8K and A10K self-assemble in water into ca. 100 nm long ribbon-like aggregates. These structures can be described as ?-sheets laminated into a ribbon structure with a constant elliptical cross-section of 4 by 8 nm, where the longer axis corresponds to a finite number, N ? 15,…
(Natural) polymersApplicationCharacterizationCompositesCustomer publicationsFractal dimensionMaterialParticle interactionsParticlesPolymer researchSAXSTechnique

Morphologies of Polyisoprene-Grafted Silica Nanoparticles in Model Elastomers

Bonnevide, Marine; Jimenez, Andrew M.; Dhara, Deboleena; Phan, Trang N.T.; Malicki, Nicolas; Abbas, Zaid M.; Benicewicz, Brian; Kumar, Sanat K.; Couty, Marc; Gigmes, Didier; Jestin, Jacques

We control nanoparticle (NP) dispersion by leveraging the entropic and enthalpic effects associated with mixing silica NPs grafted with polyisoprene (PI) chains into matrices of varying degrees of chemical dissimilarity. Previous work in this area has primarily focused on entropic factors alone, and hence, this work represents a significant advance…
ApplicationCharacterizationCustomer publicationsMaterialNanoparticles & colloidsParticle interactionsParticle size and size distributionParticlesSAXSTechnique

Colloidal Solubility and Agglomeration of Apolar Nanoparticles in Different Solvents

Doblas, David; Kister, Thomas; Cano-Bonilla, Marina; González-García, Lola; Kraus, Tobias

We studied the concentration-dependent agglomeration of apolar nanoparticles in different solvents. Octanethiol-stabilized gold nanoparticles (AuNPs) in evaporating liquid droplets were observed in situ using small-angle X-ray scattering. Concurrent analysis of liquid volume and particle agglomeration provided time-dependent absolute concentrations of free and agglomerated particles. All…
(Natural) polymersCompositesCustomer publicationsParticle interactionsPolymer researchWAXS

Amino-functionalized breath-figure cavities in polystyrene–alumina hybrid films: effect of particle concentration and dispersion

V, Lakshmi; Raju, Annu; G, Resmi V.; Pancrecious, Jerin K.; D, Rajan T. P.; C, Pavithran

We report the formation of breath-figure (BF) patterns with amino-functionalized cavities in a BF incompatible polystyrene (PS) by incorporating functionalized alumina nanoparticles. The particles were amphiphilic-modified and the modifier ratio was regulated to achieve a specific hydrophobic/hydrophilic balance of the particles. The influence of the physical and chemical properties of…
12 March 2019