Category

Material

ApplicationCharacterizationCustomer publicationsLipidsMaterialPhase analysisSAXSSizeStructural biologyTechnique

Immobilisation of ?-galactosidase within a lipid sponge phase: structure, stability and kinetics characterisation

Gilbert, Jennifer; Valldeperas, Maria; Dhayal, Surender K.; Barauskas, Justas; Dicko, Cedric; Nylander, Tommy

In the formulation of an active enzyme enclosed in a matrix for controlled delivery, it is a challenge to achieve a high protein load and to ensure high activity of the protein. For the first time to our knowledge, we report the use of a highly swollen lipid sponge (L3)…
27 January 2020
ApplicationCharacterizationCustomer publicationsMaterialParticle interactionsProteins & DNA/RNASAXSStructural biologyTechnique

Studying Excipient Modulated Physical Stability and Viscosity of Monoclonal Antibody Formulations Using Small-Angle Scattering

Xu, Amy Yuanyuan; Castellanos, Maria Monica; Mattison, Kevin; Krueger, Susan; Curtis, Joseph E.

Excipients are substances that are added to therapeutic products to improve stability, bioavailability, and manufacturability. Undesirable protein-protein interactions (PPI) can lead to self-association and/or high solution viscosity in concentrated protein formulations that are typically greater than 50 mg/mL. Therefore, understanding the effects of excipients on nonspecific PPI is important for…
27 January 2020
ApplicationCharacteristic dimensionCharacterizationCustomer publicationsGISAXSInorganic materialMaterialOrientation analysisPhase analysisRenewable energySAXSSurface structure and patternsTechniqueThin films

Tuning Pore Dimensions of Mesoporous Inorganic Films by Homopolymer Swelling

Reid, Barry; Alvarez-Fernandez, Alberto; Schmidt-Hansberg, Benjamin; Guldin, Stefan

The functionality and applications of mesoporous inorganic films are closely linked to their mesopore dimensions. For material architectures derived from a block copolymer (BCP) micelle coassembly, the pore size is typically manipulated by changing the molecular weight corresponding to the pore-forming block. However, bespoke BCP synthesis is often a costly…
27 January 2020
ApplicationCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSShapeSizeStructural biologyTechnique

Tandem catalysis in multicomponent solvent-free biofluids

Atkins, Dylan Luke; Berrocal, José Augusto; Mason, Alexander Francesco; Voets, Ilja Karina

Enzymes are widely employed to reduce the environmental impact of chemical industries as biocatalysts improve productivity and offer high selectively under mild reaction conditions in a diverse range of chemical transformations. The poor stability of biomacromolecules under reaction conditions is often a critical bottleneck to their application. Protein engineering or…
27 January 2020
ApplicationCharacterizationCustomer publicationsMaterialNanoparticles & colloidsParticle size and size distributionParticlesSAXSTechnique

A Cross-Method Comparison of Sub-10 nm Nanoparticle Size Distribution

Yang, Ye; Liao, Suiyang; Luo, Zhi; Qi, Runzhang; Mac Fhionnlaoich, Niamh; Stellacci, Francesco; Guldin, Stefan

Accurate nanoparticle (NP) size determination is essential across research domains, with many functions in nanoscience and biomedical research being size-dependent. Although transmission electron microscopy (TEM) is capable of resolving a single NP down to the sub-nm scale, the reliable representation of entire populations is plagued by challenges in providing statistical…
27 January 2020
(Natural) polymersApplicationCharacteristic dimensionCharacterizationCustomer publicationsMaterialPolymer researchSAXSSelf-assembled materialTechnique

Fragmentation of 1,2-Polybutadiene-block-Poly(ethylene oxide) Micelles in Imidazolium-Based Ionic Liquids

Early, Julia T.; Lodge, Timothy P.

The effect of solvent selectivity on the fragmentation kinetics of spherical micelles formed by a 1,2-polybutadiene-block-poly(ethylene oxide) “BO” copolymer in five 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide-based ionic liquids (ILs), (, where n = methyl, ethyl, butyl, hexyl, and octyl) was investigated by temperature-jump dynamic light scattering (T-jump DLS),…
27 January 2020
ApplicationCharacterizationCustomer publicationsLipidsMaterialOtherPhase analysisSAXSSizeTechniqueTemperature

Antimicrobial and cytotoxic activity of (thio)alkyl hexopyranosides, nonionic glycolipid mimetics

Džubák, Petr; Gurská, So?a; Bogdanová, Kate?ina; Uhríková, Daniela; Kanjaková, Nina; Combet, Sophie; Klunda, Tomáš; Kolá?, Milan; Hajdúch, Marian; Poláková, Monika

A series of 19 synthetic alkyl and thioalkyl glycosides derived from d-mannose, d-glucose and d-galactose and having C10–C16 aglycone were investigated for cytotoxic activity against 7 human cancer and 2 non-tumor cell lines as well as for antimicrobial potential on 12 bacterial and yeast strains. The most potent compounds were…
27 January 2020
(Natural) polymersApplicationCharacterizationCustomer publicationsMaterialOrientation analysisPolymer researchSAXSTechnique

Structure Evolution and Deformation Behavior of Polyethylene Film during Biaxial Stretching

Chen, Qiang; Wang, Zhiwei; Zhang, Sumei; Cao, Ya; Chen, Jinyao

The structure evolution and deformation behavior of tenter-frame biaxially oriented polyethylene (TF-BOPE) films were investigated in this study. For sequential biaxial stretching, the original spherulites were broken into small pieces, and the fibrillar structure simultaneously formed during the machine direction (MD) stretching. Subsequently, the single fibrils were pulled away, and…
27 January 2020
(Natural) polymersApplicationCharacterizationCrystalline fractionCustomer publicationsMaterialOrientation analysisPolymer researchTechniqueWAXS

Tailored crystalline order of nascent polyethylene from metallocene supported on confined polystyrene

Wu, Yanjie; Yang, Huaqin; Li, Wei; Mattea, Carlos; Stapf, Siegfried; Zhang, Letian; Ye, Chunlin; Ye, Xiaofeng

Building the desirable superstructure of polyethylene is one of the important topics for developing high value-added products, which brings potential benefits for society and sustainable development. Crystalline order is the ubiquitous superstructure for enhancing mechanical properties of polymeric materials. In this work, polystyrene copolymers (c-PS) are incorporated into pores of…
27 January 2020
ApplicationCharacteristic dimensionCharacterizationCustomer publicationsMaterialPorous materialRenewable energySAXSSpecific surfaceTechnique

Unveiling the role of hydrothermal carbon dots as anodes in sodium-ion batteries with ultrahigh initial coulombic efficiency

Xie, Fei; Xu, Zhen; Jensen, Anders C. S.; Ding, Feixiang; Au, Heather; Feng, Jingyu; Luo, Hui; Qiao, Mo; Guo, Zhenyu; Lu, Yaxiang; Drew, Alan J.; Hu, Yong-Sheng; Titirici, Maria-Magdalena

Hard carbon materials are regarded as the most promising anode materials for sodium-ion batteries (SIBs) due to their best cost-effectiveness. However, their relatively low specific capacity and initial Coulombic efficiency (ICE) compared with the graphite anode in lithium-ion batteries still limit the energy density for further development. Thus, it is…
27 January 2020