Monthly Archives

March 2019

Application notes

Thorough investigation of oligomers during protein fibrillation

The transient nature of aggregates during the fibrillation process of α-synuclein is highlighted with in-house SAXS experiments using the BioXolver. Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the…
Marie
19 March 2019
Application notesApplication notes-Pharma

Protein-protein interactions – from in vivo functionality to pharmaceutics and food science

Salt concentration and pH impact were studied on lysozyme and BSA systems respectively by investigating various parameters (osmotic second virial coefficient, folding state and 3D shape). Protein-protein interactions are relevant for various biological processes, such as transcription and signal transduction, but also for protein crystallization, stability and shelf-life of pharmaceutical…
Marie
19 March 2019
Success story

Arkema and the Nano-inXider

As a designer of materials and innovative solutions, Arkema shapes materials and creates new uses that accelerate customer performance in lightweight and design materials, biosourced materials, new energies, water management, solutions for electronics, and the performance and home insulation. For the development of new polymers, Arkema used to characterize materials…
Marie
15 March 2019
Application notesApplication notes-Pharma

High throughput protein envelope determination

3D envelopes were determined from an automated sequence of measurements including 3 different proteins with low volume and dilute solutions. Small-angle X-ray scattering is complementary to other structural biology techniques. It provides reliable information on the shape of proteins in solution and associated parameters including macromolecule interactions and dynamics. Reliability of the…
Marie
14 March 2019
ApplicationCharacteristic dimensionCharacterizationCustomer publicationsLiquid crystalsMaterialOtherPhase analysisSAXSSurfactantsTechnique

Liquid crystal phantom for validation of microscopic diffusion anisotropy measurements on clinical MRI systems

Nilsson, Markus; Larsson, Johan; Lundberg, Dan; Szczepankiewicz, Filip; Witzel, Thomas; Westin, Carl-Fredrik; Bryskhe, Karin; Topgaard, Daniel

Purpose To develop a phantom for validating MRI pulse sequences and data processing methods to quantify microscopic diffusion anisotropy in the human brain. Methods Using a liquid crystal consisting of water, detergent, and hydrocarbon, we designed a 0.5-L spherical phantom showing the theoretically highest possible degree of microscopic anisotropy. Data…
Xenocs
12 March 2019
Customer publications

Comb-shaped anion exchange membrane to enhance phosphoric acid purification by electro-electrodialysis

Duan, Xiaoling; Wang, Cunwen; Wang, Tielin; Xie, Xiaolin; Zhou, Xingping; Ye, Yunsheng

Comb-shaped polysulfone anion exchange membranes (AEMs) containing various pendant alkyl side chains were synthesized and characterized. Ionic clusters aggregation is observed in transmission electron microscopy (TEM) image and small-angle X-ray scattering (SAXS). The comb-shaped quaternized ammonium polysulfone (Cx-QAPSU) membranes show enhanced dimensional stability and ultra-low membrane area…
Xenocs
12 March 2019