Proteins & DNA/RNA

ApplicationCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSShapeStructural biologyTechnique

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

Kulkarni, Prakash; Jolly, Mohit Kumar; Jia, Dongya; Mooney, Steven M.; Bhargava, Ajay; Kagohara, Luciane T.; Chen, Yihong; Hao, Pengyu; He, Yanan; Veltri, Robert W.; Grishaev, Alexander; Weninger, Keith; Levine, Herbert; Orban, John

Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate-Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of the Activator Protein-1 (AP-1) transcription factor. Homeodomain-Interacting Protein Kinase 1 (HIPK1)…
12 March 2019
(Natural) polymersApplicationCharacteristic dimensionCharacterizationCustomer publicationsLiquid crystalsMaterialPhase analysisPolymer researchPore size and pore size distributionProteins & DNA/RNASelf-assembled materialTechniqueWAXS

Size-Selective Adsorption in Nanoporous Polymers from Coumarin Photo-Cross-Linked Columnar Liquid Crystals

Concellón, Alberto; Schenning, Albertus P. H. J.; Romero, Pilar; Marcos, Mercedes; Serrano, José Luis

We have prepared nanoporous polymers from columnar hexagonal hydrogen-bonded complexes, whose order is fixed by coumarin photoinduced cycloaddition (photodimerization). Two different hydrogen-bonded complexes were used and consisted of a melamine (M) or tris(triazolyl)triazine (T) derivative acting as central templates and three peripheral carboxylic acids containing coumarin units. These…
12 March 2019
ApplicationCharacterizationCustomer publicationsMaterialParticle size and size distributionProteins & DNA/RNASAXSSelf-assembled materialStructural biologyTechniqueTemperature

Temperature-Induced Self-Assembly of the Group B Streptococcus (GBS) Fusion Antigen GBS-NN

Rose, Fabrice; Roovers, Silke; Fano, Mathias; Harloff-Helleberg, Stine; Kirkensgaard, Jacob J.K.; Hejnaes, Kim; Fischer, Per; Foged, Camilla

Group B Streptococcus (GBS) is a leading cause of serious bacterial neonatal infections worldwide, which provides an unmet medical need for a globally effective vaccine. The recombinant GBS fusion antigen GBS-NN contains the N-terminal regions of the GBS Rib and Alpha C proteins. It shows promising immunogenicity eliciting protective immunity…
12 March 2019