Category

Proteins & DNA/RNA

ApplicationCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSShapeStructural biologyTechnique

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

Kulkarni, Prakash; Jolly, Mohit Kumar; Jia, Dongya; Mooney, Steven M.; Bhargava, Ajay; Kagohara, Luciane T.; Chen, Yihong; Hao, Pengyu; He, Yanan; Veltri, Robert W.; Grishaev, Alexander; Weninger, Keith; Levine, Herbert; Orban, John

Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate-Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of the Activator Protein-1 (AP-1) transcription factor. Homeodomain-Interacting Protein Kinase 1 (HIPK1)…
Xenocs
12 March 2019
Customer publicationsProteins & DNA/RNASAXSShapeStructural biology

Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components

Razew, Michal; Warkocki, Zbigniew; Taube, Michal; Kolondra, Adam; Czarnocki-Cieciura, Mariusz; Nowak, Elzbieta; Labedzka-Dmoch, Karolina; Kawinska, Aleksandra; Piatkowski, Jakub; Golik, Pawel; Kozak, Maciej; Dziembowski, Andrzej; Nowotny, Marcin

The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal structure and give insights into its…
Xenocs
12 March 2019
CharacterizationCustomer publicationsLipidsProteins & DNA/RNASAXSStructural biology

Rheological Link Between Polymer Melts with a High Molecular Weight Tail and Enhanced Formation of Shish-Kebabs

Wingstrand, Sara L.; Shen, Bo; Kornfield, Julie A.; Mortensen, Kell; Parisi, Daniele; Vlassopoulos, Dimitris; Hassager, Ole

Presence of an ultra high molecular weight (UHMw) fraction in flowing polymer melts is known to facilitate formation of oriented crystalline structures significantly. The UHMw fraction manifests itself as a minor tail in the molar mass distribution and is hardly detectable in the canonical characterization methods. In this study, alternatively,…
Xenocs
12 March 2019