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Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components

Razew, Michal; Warkocki, Zbigniew; Taube, Michal; Kolondra, Adam; Czarnocki-Cieciura, Mariusz; Nowak, Elzbieta; Labedzka-Dmoch, Karolina; Kawinska, Aleksandra; Piatkowski, Jakub; Golik, Pawel; Kozak, Maciej; Dziembowski, Andrzej; Nowotny, Marcin

By 12 March 2019April 22nd, 2019No Comments

Nature Communications, 2018, vol 9, 1, pp. 97

DOI:10.1038/s41467-017-02570-5

Abstract

The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal structure and give insights into its mechanism.

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