Probing the effect of oxidation on model lipid bilayers.

Introduction

The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such as inflammation and infection. Successful treatment of such conditions requires a detailed understanding of the underlying processes. Biological membranes are however highly complex systems with a multitude of different components, rendering their investigation very challenging. Vesicles/liposomes can serve as simple model systems for biological membranes allowing to study the effect of external factors on lipid bilayers.