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Smart release of antimicrobial ZnO nanoplates from a pH-responsive keratin hydrogel

Villanueva, María E.; Cuestas, María L.; Pérez, Claudio J.; Campo Dall′ Orto, Viviana; Copello, Guillermo J.

By 12 March 2019 April 22nd, 2019 No Comments

Journal of Colloid and Interface Science, 2019, vol 536pp. 372-380



A smart antibacterial biomaterial based on a keratin hydrogel with pH-dependent behavior and Zinc Oxide nanoplates as biocide agent has been developed. The pH of a chronic wound is basic due to bacterial metabolism. Originally shrank at acid pH, keratin hydrogels swell upon contact with a bacterial contaminated media leading to the release of the nanoparticles. The material has been thoroughly characterized by infrared spectroscopy, Raman, scanning electron microscope, swelling behavior, Differential scanning calorimetry, Small-angle X-ray scattering, rheology, antimicrobial activity and cytotoxicity. The results show that 5% of Zinc Oxide nanoparticles concentration is the optimum for wound dressing applications.

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