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Type of articles

Application notes

Functional foods characterization at the nanoscale using SAXS

- Application highlight - Development of nanocarriers for functional food delivery is an active area of research. Both the development and the production process require characterization techniques that provide information about how nutrient loading and processing conditions influence the final structure and stability of nanocarriers and their dispersion in food.…
24 January 2020
Application notes

Vesicles

Probing the effect of oxidation on model lipid bilayers. The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such…
25 June 2019
Application notes

Microgels

Screening of stimuli-responsive colloidal particles. Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing triggered release of encapsulated bioactive molecules. They additionally protect these loaded…
18 June 2019
Application notes

Thorough investigation of oligomers during protein fibrillation

The transient nature of aggregates during the fibrillation process of α-synuclein is highlighted with in-house SAXS experiments using the BioXolver. Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the…
19 March 2019
Application notes

In-lab SEC-SAXS for structural investigation of complex samples

SAXS data and 3D envelopes of small and large protein species are obtained through in-line gel filtration. Small-angle X-ray scattering (SAXS) is commonly used to investigate the solution structure of biological macromolecules. Highly accurate results can be obtained with monodisperse solutions devoid of aggregates and impurities. Many biological processes, however,…
19 March 2019
Application notes

Protein-protein interactions – from in vivo functionality to pharmaceutics and food science

Salt concentration and pH impact were studied on lysozyme and BSA systems respectively by investigating various parameters (osmotic second virial coefficient, folding state and 3D shape). Protein-protein interactions are relevant for various biological processes, such as transcription and signal transduction, but also for protein crystallization, stability and shelf-life of pharmaceutical…
19 March 2019
Success story

Arkema and the Nano-inXider

As a designer of materials and innovative solutions, Arkema shapes materials and creates new uses that accelerate customer performance in lightweight and design materials, biosourced materials, new energies, water management, solutions for electronics, and the performance and home insulation. For the development of new polymers, Arkema used to characterize materials…
15 March 2019