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The sulfated polysaccharide from a marine red microalga as a platform for the incorporation of zinc ions

Netanel Liberman, Gal; Ochbaum, Guy; (Malis) Arad, Shoshana; Bitton, Ronit

By 12 March 2019No Comments

Carbohydrate Polymers, 2016, vol 152pp. 658-664

DOI:10.1016/j.carbpol.2016.07.025

Abstract

The cell-wall sulfated polysaccharide of the marine red microalga Porphyridium sp. is a high molecular weight biopolymer that has potential for use as a platform for metal complexation for various applications. This paper describes the structural and rheological characterization and antibacterial activity of the polysaccharide in combination with Zn2+ (Zn-PS). SAXS and rheology studies indicate that with the addition of ZnCl2 to the sulfated polysaccharide the only change was the increase in viscosity in the entangled regime. The antibacterial activity of Zn-PS solutions was more potent than that of the native polysaccharide against Gram-negative and Gram-positive bacteria. The synergy between the bioactivities of Zn2+ (which is a key player in wound healing and is active against variety of pathogens) and the unique bioactivities of the polysaccharide (e.g., anti-inflammatory) indicates promising potential for the development of novel products for the pharmaceutical and cosmetics industries.

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