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Polysaccharide and poly(methacrylic acid) based biodegradable elastomeric biocompatible semi-IPN hydrogel for controlled drug delivery

Ganguly, Sayan; Maity, Priti Prasanna; Mondal, Subhadip; Das, Poushali; Bhawal, Poushali; Dhara, Santanu; Das, Narayan Ch.

By 12 March 2019No Comments

Materials Science and Engineering: C, 2018, vol 92pp. 34-51



Nanoparticles embedded semi-interpenetrating (semi-IPNs) polymeric hydrogels with enhanced mechanical toughness and biocompatibility could have splendid biomedical acceptance. Here we propose poly(methacrylic acid) grafted polysaccharide based semi-IPNs filled with nanoclay via in situ Michael type reaction associated with covalent crosslinking with N,N-methylenebisacrylamide (MBA). The effect of nanoclay in the semi-IPN hydrogel has been investigated which showed significant improvement of mechanical robustness. Meanwhile, the hydrogels showed reversible ductility up to 70% in response to cyclic loading-unloading cycle which is an obvious phenomenon of rubber-like elasticity. The synthesized semi-IPN hydrogel show biodegradability and non-cytotoxic nature against human cells. The live-dead assay showed that the prepared hydrogel is a viable platform for cell growth without causing severe cell death. The in vitro drug release study in psychological pH (pH = 7.4) reveals that the controlled drug release phenomena can be tuned by simulating the environment pH. Such features in a single hydrogel assembly can propose this as high performance; biodegradable and non-cytotoxic 3D scaffold based promising biomaterial for tissue engineering.

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