Dr. Cyr’s scientific career began with work in biochemical engineering, then protein NMR spectroscopy, and infectious disease research, providing him with a robust foundation in both the mechanistic and functional characterization of biomolecules. This experience now informs his focus on solution-state structural methods, particularly for studying dynamic complexes, heterogeneous mixtures, and transient interactions.
Through his role at the structural biology core, Dr. Cyr supports a wide range of collaborative projects, offering expertise in instrumentation, experimental design, and data analysis. He takes a practical approach to open science and cross-disciplinary collaboration, aiming to make solution-based structural methods more accessible and effective for studying biomolecular function. His work contributes to a growing number of peer-reviewed publications and continues to connect practical innovation with biological insight.
From mixtures to models: exploring macromolecular complexes with laboratory SEC-SAXS
Size-exclusion chromatography coupled with small-angle X-ray scattering (SEC-SAXS) has become a powerful method to study the solution structures of biomolecular complexes and heterogeneous samples. In this webinar, we introduce a unique laboratory-based SEC-SAXS setup, tailored for the structural analysis of proteins, macromolecular assemblies, and dynamic mixtures. We will present the instrumental configuration, share best practices for data collection and troubleshooting, and guide participants through the data analysis workflow. Published case studies from our lab will illustrate the practical impact of SEC-SAXS in uncovering structural insights from challenging samples. This session is designed for structural biologists, biochemists, and researchers interested in advanced solution-state biophysics.
