Seeing biologics and nanocarriers in solution: Practical SAXS for the pharmaceutical lab

Small-angle X-ray scattering (SAXS) measures the size, shape, flexibility and internal structure of proteins, liposomes and lipid nanoparticles directly in solution. It needs no crystals, no labels and only microliters of sample. In this webinar we cover the basics of SAXS and walk through a practical analysis workflow: buffer subtraction, judging data quality, high-throughput screening and modelling. We compare in-house SAXS instruments with synchrotron beamlines and explain when a lab system is the better choice for development and QC. We then show real pharma examples: ligand-induced conformational changes in a drug target, PEG corona and lamellarity of liposomes, and ordered lipid–mRNA structures. No prior SAXS experience is required.