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Presented by
Dr. Suzette Pabit
Dr. Suzette Pabit is an Associate Principal Scientist at Merck & Co., Inc. based in West Point, PA, USA (Merck & Co., Inc is … Dr. Suzette Pabit is an Associate Principal Scientist at Merck & Co., Inc. based in West Point, PA, USA (Merck & Co., Inc is known as MSD outside of the United States and Canada). She is part of the Materials and Biophysical Characterization group where she uses Small Angle X-ray Scattering (SAXS) and other biophysical tools to support Analytical Research and Development of vaccines, biologics and others. Suzette has a Ph.D. in Physics from the University of Florida. Prior to joining Merck, she spent a large part of her career at Cornell University using both synchrotron and lab-based SAXS to understand protein and nucleic acid conformations.
Organizer
Dr. Soren Skou

Correlating SAXS and Cryo-EM for High-Throughput Liposome and LNP Analysis

Webinar

Advanced biophysical characterization can accelerate the development of emerging drug modalities like liposomes and lipid nanoparticles (LNPs). Cryogenic electron microscopy (cryo-EM) is widely employed to assess liposome lamellarity and LNP morphology but the technique has low data throughput. Small Angle X-ray Scattering (SAXS) offers complementary size and shape information of nanoparticles in solution with higher throughput, especially when combined with robotics-enabled automated sampling. In this webinar, we show how we correlated cryo-EM imaging with SAXS measurements to enable SAXS as a rapid screening tool in pharmaceutical process and formulation development for liposomes and LNPs.

Register now to learn:

01

The utility of SAXS in pharmaceutical development

02

How SAXS is applied to liposome and LNP characterization

03

Model fitting of SAXS liposome data using SaSView

04

Current trends and limitations in fitting and modeling of SAXS LNP data

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