News & events - Xenocs

Events

BPS 2022

19-23 February, 2022. Xenocs is very pleased to attend the 66th Biophysical Society Annual Meeting from February 19 to 23, 2022 in San Francisco, USA. Meet us at our booth!

Events Type of articles

ESRF User Meeting 2022

7-9 February, 2022. Xenocs is very pleased to attend the ESRF User Meeting 2022 from February 7 to 9, 2022. Meet us at our virtual booth!

News

New General Manager at Xenocs China

We are pleased to announce the arrival of Tao Lu as Xenocs China new General Manager and legal representative.

News

CAPZA Growth Tech makes investment in Xenocs, a worldwide technological leader in nanoscale material analysis

Press release - Paris, May 25th, 2021

Events

SAXS in the Pharmaceutical Industry

Short online course
22 & 24 June 2021 14:00–16:10 CEST

Xenocs and BIOSAXS invite you to join our interactive two-day short course focused on the benefits and use of Small Angle X-ray Scattering (SAXS) for the pharmaceutical industry.

News

XSACT 2.0: New software for X-ray scattering data processing and analysis

We are proud to present XSACT 2.0!, our all in-one solution for X-ray scattering data analysis.

Events

Join DTI Webinar: why you should use X-rays in formulation of biologics

On December 10, 2020, 15.00-16.00 (CET), the Danish Technological Institute together with BioPeople will host a webinar with renowned Xenocs customers titled “Why you should use X-rays in formulation of biologics”

Events

Oléron 2020

9-16 October 2020, Oléron, France. 7th National School in Integrative Structural Biology.

News

Xenocs participates in Mobility Challenge for cleaner commuting

Xenocs will participate this year in the Mobility Challenge Day organized by the Auvergne-Rhône-Alpes Region, France, to promote ‘clean’ transport modes.

News

Covid-19 – Letter from Xenocs Management

By Xenocs CEO Peter Høghøj and Managing Director Frédéric Bossan

Events

EP 2019

7-10 August 2019, Yinchuan, China.

Events

Join our next training webinar

Xenocs is pleased to welcome you to our new training webinar sessions. Join us for “Measurement of low concentration aqueous solutions. The Low Noise Flow Cell. Part 2." The second part of the webinar will deal with the data reduction process and data analysis. Date: July, Thursday 18th 2019 Two…

Events



Source	Microfocus sealed tube: Cu, 30 W / 30 µm, point focus. ( DIN EN 12543-5) Polychromatic Copper microfocus source for imaging a field of view of 14 mm x 14 mm. MetalJet F10 source (Ga), 250 W / 20 µm Rotating anode X-ray sources (Cu and Cr/Mo/Co on demand) 1.2 / 3 kW - 70 μm Motorized Dual or Triple source (Microfocus sealed tube: Cu/Mo/Cr combined with MetalJet or Microfocus rotating anode)
Optics	Patented 3D single reflection multilayer optics.
Detector	In-vacuum motorized 3-axis detectors for 2D SAXS/WAXS (Q-Xoom): --Eiger2 R (500K, 1M or 4M) hybrid photon counting detectors Optional WAXS detectors for SWAXS: --Motorized 3-axis Eiger2 R 500K hybrid photon counting detector
Sample chamber	Large vacuum chamber. On-axis sample viewing (parallax free). Attachments for operation of sample in air. XL station: Dedicated air-space tailored for accommodating extra-large sample environments
Key features	Clean Beam technology: High flux and low background beamline. Beamstopless measurement: SAXS acquisition continuously without any beamstop. Q-Xoom: Automatic change of measurement configuration over all instrument Q-range with no movement of sample measuring position and automatic callibations. Virtual detector mode: Surfaces of detection > 200 mm x 200 mm.
Measurement capability	Nanoparticles size up to 250 nm, 500 nm or 900 nm in diameter depending on the Xeuss model. Nanoparticles size up to > 2.5 microns with optional motorized Bonse-Hart module for automatic sequential USAXS/SAXS/WAXS measurements. Nanoparticles sizes down to 50 nm can be measured using the AuX source on spot sizes of 150 microns and with measuring times in the range of a minute or less. Scattering measurements up to 2Ɵ > 70° with Q-Xoom. Qmax > 49 nm-1 The X-ray imaging option extends the range of structural information from Å to mm while the Dark-field and Phase-contrast imaging (DF-PCI) option reveals nanostructure differences, interfaces and orientation.
Sample environment	Standard holders (multi-samples): solids, capillaries, powders and gels. Flowcells for liquids: --- Low noise flowcell --- Capillary flowcell --- Automatic Sample Changer --- BioCube measuring cell with dynamic monitoring (compatible with pipetting robot) Temperature stages: --- Multi-purpose X-Ray temperature stage (-30°C to 150°C) --- High temperature sample stage (-150°C to 350°C) --- Extended high-temperature sample stage (ambient to 1000°C) Mechanical stress stages: --- Tensile Stage (0 N to 600N). --- Couette stage for shear SAXS. --- Cryo-Shear Cell (-50°C to +450°C). Humidity stage (5% to 95% humidity at temperatures ranging from 10°C to 70°C). Temperature compatible advanced GISAXS stage with incidence angle control and additional rotation for texture or in-plane scattering analysis Other sample stages available under request
Software	Comprehensive Software Suite: Xplore: command and control software for intuitive data acquisition with automatic data reduction in absolute units and live data display providing also real-time equipment monitoring and scripting capabilities from any programming language. XSACT Pro (X-ray Scattering Analysis and Calculation Tool) for data analysis and interpretation including unique modules for particle shape determination through direct modeling or AI-powered classification.
General parameters	Models & Footprint: Xeuss Pro C (1 m x 3.5 m), HR (1 m x 5 m), UHR (1 m x 8 m). Maximum power consumption: 4.8kW (single phase power)



Source and optics	Microfocus sealed tube: Cu, 30W/30µm, point focus. ( DIN EN 12543-5) Patented 2D single reflection multilayer optics.
Detector	Dectris Pilatus 3 hybrid photon counting detectors. Two fixed detectors for continuously and simultaneously. SAXS and WAXS acquisition up to 2θ=60°.
Beam Path	Windowless beam path entirely under vacuum from beam delivery system to detector sensor
Key features	Clean Beam technology: high flux and low background beamline. Beamstopless measurement: SAXS acquisition continuously without any beamstop. Virtual detector mode: > 200° azimuth coverage with rotation of sample.
Measurement capability	Nanoparticles size up to 250 nm in diameter.
Sample environment	Standard holders: solids, capillaries, powders. Sample holders for powders and gels. Flow cells for liquids: --- Low noise flow cell --- Capillary flow cell Automatic Sample Changer Temperature stages: --- Multi-purpose X-Ray Temperature Stage (-20°C to 150°C) --- High temperature sample stage (-150°C to 350°C) --- Extended high temperature sample stage (amb - 700°C) Tensile Stage (0-200N). GiSAXS stage compatible with high temperature sample stage. Custom stages on request.
Software	Acquisition software with automatic data reduction in absolute units and live data display. XSACT (X-ray Scattering Analysis and Calculation Tool) for data analysis and interpretation.
General parameters	Fooprint: < 1x1 m². Weight: ~ 520 kg. Maximum power consumption: < 2000 W (single phase power). Self-contained: no external fluids required.
Warranty	Two years warranty and three years on X ray source.


BioXolver configurations	BioXolver	BioXolver L
Utilisation	Research on biological macro-molecules in solution	Research on biological macro-molecules, including large complexes and interactions
X-ray source	Microfocus GeniX 3D, MetalJet, add-on to RAG	0.02-0.3nm
Optic	Aspheric single reflection multilayer optic
Collimation	Motorized scatterless point collimation	variable
Sample cell	Xenocs thermalized BioCube flow-cell with camera and pump
Sample handling	Pipetting robot with disposable tips
Sample capacity	Up to 2 x 96 well plates (thermalized)
Minimum sample volume	Down to 5 μL
Cleaning	Automated cleaning and drying with three cleaning fluids
Detector	Dectris in-vacuum hybrid pixel photon counting detector
Detector configuration	Fixed detector distance	Variable detector distance
Data reduction and analysis software	RAW and ATSAS
Q-range and typical protein size*	0.006 Å-1 / MW < 200 MDa / Rg < 135 Å	0.003 Å-1 / MW < 1.5 GDa / Rg < 270 Å
Overall length	3.2 m (2.7 m as add-on to existing source)	4.2 m
Options	UV-Vis, separate temperature control for sample trays and BioCube	UV-Vis, separate temperature control for sample trays and BioCube
Services	Installation, training, hot-line, maintenance contract	Installation, training, hot-line, maintenance contract



Source	Microfocus sealed tube: Cu, 30W/30µm, point focus. ( DIN EN 12543-5) MetalJet source D2+ (Ga). Motorized Dual source or triple source (Cu/Mo/Cr/Ga).
Optics	Patented 2D single reflection multilayer optics.
Detector	In-vacuum motorized 3-axis detectors for 2D SAXS/WAXS (Q-Xoom): --Pilatus3 R 300K hybrid photon counting detector --Eiger2 R (1M, 4M) hybrid photon counting detectors Optional WAXS detectors for SWAXS: --Pilatus3 R 100K hybrid photon counting detector --Motorized 3-axis Eiger2 R 500K hybrid photon counting detector
Sample chamber	Large vacuum chamber. On-axis sample viewing (parallax free). Attachments for operation of sample in air.
Key features	Clean Beam technology: high flux and low background beamline. Beamstopless measurement: SAXS acquisition continuously without any beamstop. Q-Xoom: Automatic change of measurement configuration over all instrument Q-range with no movement of sample measuring position. Virtual detector mode: surfaces of detection > 200 mm² x 200 mm².
Measurement capability	Nanoparticles size up to 300 nm, 500 nm or 900 nm in diameter depending on Xeuss model. Nanoparticles size up to > 2.5 microns with optional motorized Bonse-Hart module for automatic sequential USAXS/SAXS/WAXS measurements. Scattering measurements up to 2Ɵ>70° with Q-Xoom. Qmax > 49 nm^-1
Sample environment	Standard holders (multi-samples): solids, capillaries, powders. Sample holders for powders and gels. Flowcells for liquids: --- Low noise flowcell --- Capillary flowcell --- Automatic Sample Changer --- BioCube measuring cell with dynamic monitoring (compatible with pipetting robot) Temperature stages: --- Multi-purpose X-Ray Temperature Stage (-30°C to 150°C) --- High temperature sample stage (-150°C to 350°C) --- Extended high temperature sample stage (amb - 1000°C) Tensile Stage (00-600N). Humidity stage (10%-90% from ambient to 60°C). Shear stage Temperature compatible GiSAXS stage Other sample stages available under request
Software	Acquisition software with automatic data reduction in absolute units and live data display. XSACT (X-ray Scattering Analysis and Calculation Tool) for data analysis and interpretation.
General parameters	Models & Footprint : Xeuss 3.0 C (1 m x 3 m), HR (1 m x 5 m), UHR (1 m x 8 m). Maximum power consumption: < 3000 W (single phase power)


Model	Detailed specifications
Synchrotron scatterless slits (♦)	Please contact us for any technical information Discover what our customers say about it!
X-ray alignment camera (♦)	Please contact us for any technical information
Pin Diode detector (♦)	Please contact us for any technical information
Beam stop with integrated Pin Diode	Please contact us for any technical information


Mirror type	Figure	Optic efficiency (calculated over mirror length for 70µm source)
Standard Montel mirrors		Eff = 42%
Xenocs FOX 3D mirrors		Eff = 62%


Model	Beam size at focus (mm) with 60 µm source	Divergence (mrad)	Typical application
FOX 3D Cu 14-39 (♦)	0.19 x 0.19	5.4	Protein crystallography (♦) Powder diffraction
FOX 3D Cu 12-53	0.3 x 0.3	3	Protein crystallography (Long Unit Cells) Powder diffraction
FOX 3D Mo 10-31	0.13 x 0.13	4	Small molecule crystallography High pressure diffraction
FOX 3D Ag 10-30	0.13 x 0.13	3	Small molecule crystallography High pressure diffraction
FOX 3D Cr 8-30	0.20 x 0.20	6	Protein crystallography (S-SAD) Stress analysis
FOX 1D Cu 12-53	0.3	3	XRD, Powder Diffraction


Element of interest	Reference
O, F, Na, Mg, Al, Si, P, S	XAN-1
Nitrogen	XAN-2
Carbon	XAN-3
Boron	XAN-4
Mg, Al , Si	XAN-5
Be	XAN-6


Model	Beam size at focus (µm)	Divergence (mrad)	Flux (ph/sec)	Typical application
GeniX 3D Cu High Flux *	< 190	6	> 400 x 10⁶	Protein crystallography Micro stress analysis Powder diffraction
GeniX 3D Mo High Flux	< 130	5	> 25 x 10⁶	Small Molecule crystallography High pressure
GeniX 3D Cr High Flux	< 190	6	> 300 x 10⁶	Stress Analysis
GeniX 3D Cu High Convergence *	60	70 x 35	> 400 x 10⁶	Rapid X-ray Reflectometry (full beam) Scanning x-ray reflectometry (with slit) Micro x-ray fluorescence Small spot diffraction on thin film
GeniX 3D Cu Low Convergence *	< 250	3	> 120 x 10⁶	Small Angle X-ray Scattering Protein Crystallography

智能工作流程和用户体验

使用XSACT可使用户用最小投入获得数据解析结果。

样品 – 测试 – 分析 – 报告 – 节约时间

Nano-inXider specifications

BioXolver specifications

*Theoretical limit assuming globular proteins

Xeuss 3.0 specifications

更高的灵活性

为广大用户群体提供全远程自动操作的、具备表征超大纳米尺度范围的独特工具。

Q-Xoom–享受全范围计算机控制探测器行程的灵活性

测量尺度可达4.5微米，并获取纳米尺度信息

对任何种类样品(吸收，荧光，特征尺寸)的实验进行优化

直接从样品到结果

通过Nano-inXider智能化的设计，只需将您的样品放置在样品仓里即可。然后就能得到结果。过程非常简单快捷。

样品

测试

分析

报告

节约时间

Nano-inXider数据采集软件具有以下用户友好的互动界面:

无需任何用户干预，自动工作流程可以进行以下所有数据处理

XSACT：X射线散射分析和计算工具

X射线光束附件

除了我们的高质量的聚焦镜元件和光束传输系统，我们还提供可选配件供您选择，以使您的设备能达到最优配置。

X射线聚焦镜

Xenocs为XRD和XRF应用提供了许多不同种类的聚焦镜。

2D-3D光束成型X射线聚焦镜

高通量聚焦镜

小光斑聚焦镜

准直聚焦镜

1D光束成型X射线聚焦镜

高通量聚焦镜

准直聚焦镜

XRF聚焦镜

X射线光束传输系统

创新的设计和FOX3D单反射聚焦镜的结合使GeniX3D成为市场上独特的解决方案。

高通量解决方案

小焦斑解决方案

SAXS可以和在线SEC、UV-Vis联用 – 在实验室也可以实现!

通过内置胶体过滤获取不同尺寸蛋白质种类的结构

在实验室中得到高质量SAXS数据

以前的测试只能在同步辐射完成，现在也可在实验室中实现。

高通量测量

可对高达192个样品进行全自动测试。

低样品消耗量

低至5μL。目前是市场上最低的样品消耗量。

可直接发表的高质量图片展示

XSACT结合所有工具来创建可直接发布的图表，无需其他的可视化软件，这大大节约了时间。

内容广泛、性能强大的数据分析算法软件

XSACT包括一系列的广泛的分析模块，用于对多种类型的材料包括纳米颗粒和聚合物的尺寸、结构和织构进行样品表征等。

智能工作流程和用户体验

使用XSACT可使用户用最小投入获得数据解析结果。

样品 – 测试 – 分析 – 报告 – 节约时间

低成本

通过每天获得的纳米级信息，来加快您的材料加工流程或验证您的研究模型。

同时从原子级别到纳米尺寸

无需重复SAXS和WAXS测试，您可以在一次曝光内同时得到所有测量结果。

高精度高动态范围测量

获取可信赖的数据，将您的注意力集中在科学和数据解释上。

样品空间大

Xeuss 3.0的超大样品腔有利于固定实验过程中的样品，这是目前以至今后的理想的X射线散射平台仪器。

高性能

Xeuss 3.0实验装置具备最大的灵活性，用于测试各种样品并尽可能获取最佳质量的数据。

上图显示了通过玻璃窗，可以观察到Xeuss3.0的Q-Xoom真空腔内探测器的移动。

Xeuss 3.0 specifications

BioXolver specifications

*Theoretical limit assuming globular proteins

Nano-inXider specifications

In-line SEC and UV-Vis combined with SAXS – also in the lab!

Obtain the structure of small and large protein species through in-line gel filtration

Low sample volume consumption

Down to 5μL. The lowest sample consumption on the market.

High throughput measurements and results

Full automation from sample to final results on up to 192 samples.

High quality SAXS data in the lab

Measurements previously only possible at synchrotron facilities can now be done in the lab.