Category

Shape

ApplicationCharacterizationCustomer publicationsLipidsMaterialPhase analysisSAXSShapeSizeStructural biologyTechnique

Effects of artepillin C on model membranes displaying liquid immiscibility

Pazin, W. M.; Vilanova, N.; Voets, I. K.; Soares, A. E. E.; Ito, A. S.

It has been hypothesized that the therapeutic effects of artepillin C, a natural compound derived from Brazilian green propolis, are likely related to its partition in the lipid bilayer component of biological membranes. To test this hypothesis, we investigated the effects of the major compound of green propolis, artepillin C,…
sergio.rodrigues@xenocs.com
27 January 2020
(Natural) polymersApplicationCharacterizationCustomer publicationsMaterialNanoparticles & colloidsParticlesSAXSSelf-assembled materialShapeSizeTechnique

Shape modulation of squaramide-based supramolecular polymer nanoparticles

Talens, Victorio Saez; Makurat, D. M. M.; Liu, Tingxian; Dai, Wei; Guibert, Clément; Noteborn, Willem E. M.; Voets, Ilja K.; Kieltyka, Roxanne E.

We report the synthesis and self-assembly of a library of squaramide-based bolaamphiphiles with variable hydrophobic and hydrophilic domain sizes, consisting of varied aliphatic chains (n = 2 to 12 methylene repeat units) and linear oligo(ethylene glycol) (m = 11 to 36 repeat units), to understand their effect on the formation…
sergio.rodrigues@xenocs.com
27 January 2020
(Natural) polymersApplicationCharacterizationCustomer publicationsGISAXSMaterialPhase analysisPolymer researchSAXSShapeSizeSurface structure and patternsTechnique

Adjustable self-assembly in polystyrene-block-poly(4-vinylpyridine) dip-coated thin films

Konefa?, Magdalena; Zhigunov, Alexander; Pavlova, Ewa; ?ernoch, Peter; Pop-Georgievski, Ognen; Špírková, Milena

This work studies the influence of dip-coating parameters on self-assembly in ultra-thin films of asymmetric polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) copolymers from a 1-chloropentane solution using a combination of several experimental techniques. Small-Angle X-ray Scattering, Atomic Force Microscopy, Grazing Incidence Small Angle X-ray Scattering and Transmission Electron Microscopy…
sergio.rodrigues@xenocs.com
27 January 2020
(Natural) polymersApplicationCharacterizationCompositesCustomer publicationsMaterialParticlesPolymer researchPore size and pore size distributionSAXSShapeTechnique

Understanding the Static Interfacial Polymer Layer by Exploring the Dispersion States of Nanocomposites

Genix, Anne-Caroline; Bocharova, Vera; Carroll, Bobby; Lehmann, Michelle; Saito, Tomonori; Krueger, Susan; He, Lilin; Dieudonné-George, Philippe; Sokolov, Alexei P.; Oberdisse, Julian

The dynamic and static properties of the interfacial region between polymer and nanoparticles have wide-ranging consequences on performances of nanomaterials. The thickness and density of the static layer are particularly difficult to assess experimentally due to superimposing nanoparticle interactions. Here, we tune the dispersion of silica nanoparticles in nanocomposites by…
sergio.rodrigues@xenocs.com
27 January 2020
ApplicationCharacterizationCustomer publicationsMaterialOtherParticle interactionsProteins & DNA/RNASAXSSelf-assembled materialShapeSizeStructural biologyTechnique

Twisted Ribbon Aggregates in a Model Peptide System

Rüter, Axel; Kuczera, Stefan; Pochan, Darrin J.; Olsson, Ulf

The model peptides A8K and A10K self-assemble in water into ca. 100 nm long ribbon-like aggregates. These structures can be described as ?-sheets laminated into a ribbon structure with a constant elliptical cross-section of 4 by 8 nm, where the longer axis corresponds to a finite number, N ? 15,…
sergio.rodrigues@xenocs.com
27 January 2020
(Natural) polymersApplicationCharacterizationCustomer publicationsLipidsMaterialPhase analysisSAXSShapeSizeStructural biologyTechnique

Shape and Phase Transitions in a PEGylated Phospholipid System

Viitala, Lauri; Pajari, Saija; Gentile, Luigi; Määttä, Jukka; Gubitosi, Marta; Deska, Jan; Sammalkorpi, Maria; Olsson, Ulf; Murtomäki, Lasse

Poly(ethylene glycol) (PEG) polymers and PEG-conjugated lipids are widely used in bioengineering and drug transport applications. A PEG layer in a drug carrier increases hydrophilic repulsion, inhibits membrane fusion and serum opsonin interactions, and prolongs the storage and circulation time. It can also change the carrier shape and have an…
sergio.rodrigues@xenocs.com
27 January 2020
ApplicationCharacterizationCustomer publicationsMaterialSAXSSelf-assembled materialShapeSizeStructural biologySurfactantsTechniqueTemperature

Self-Assembly of the Bio-Surfactant Aescin in Solution: A Small-Angle X-ray Scattering and Fluorescence Study

Dargel, Carina; Geisler, Ramsia; Hannappel, Yvonne; Kemker, Isabell; Sewald, Norbert; Hellweg, Thomas

This work investigates the temperature-dependent micelle formation as well as the micellar structure of the saponin aescin. The critical micelle concentration ( cmc ) of aescin is determined from the concentration-dependent autofluorescence (AF) of aescin. Values between cmcaescin,AF (10°C) = 0.38 ± 0.09 mM and cmcaescin,AF (50°C) = 0.32 ±…
sergio.rodrigues@xenocs.com
25 November 2019
ApplicationCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSShapeStructural biologyTechnique

Arguments for an additional long-lived intermediate in the photocycle of the full-length aureochrome 1c receptor: A time-resolved small-angle X-ray scattering study

Bannister, Saskia; Böhm, Elena; Zinn, Thomas; Hellweg, Thomas; Kottke, Tilman

Aureochromes (AUREO) act as blue-light photoreceptors in algae. They consist of a light-, oxygen-, voltage-sensitive (LOV) domain and a DNA-binding basic region/leucine zipper. Illumination of the flavin cofactor in LOV leads to the formation of an adduct, followed by global structural changes. Here, we first applied UV/vis spectroscopy to characterize…
sergio.rodrigues@xenocs.com
25 November 2019
ApplicationCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSShapeStructural biologyTechnique

NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution

Maszota‐Zieleniak, Martyna; Jurczak, Przemyslaw; Orlikowska, Marta; Zhukov, Igor; Borek, Dominika; Otwinowski, Zbyszek; Skowron, Piotr; Pietralik, Zuzanna; Kozak, Maciej; Szymańska, Aneta; Rodziewicz‐Motowidło, Sylwia

Human cystatin C (hCC), a member of the superfamily of papain-like cysteine protease inhibitors, is the most widespread cystatin in human body fluids. This small protein, in addition to its physiological function, is involved in various diseases, including cerebral amyloid angiopathy, cerebral hemorrhage, stroke, and dementia. Physiologically active hCC is…
sergio.rodrigues@xenocs.com
25 November 2019