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| 01/03/2004
- Protein Crystallography at EMBL test site
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With its FOX2D single reflection design, Xenocs achieved a breakthrough in the application of multilayer x‑ray optics for laboratory protein crystallography. To show that our product is not only an alternative to existing ones but rather a way to improve performance, we teamed up with Dr. Hassan Belrhali from the European Molecular Biology Laboratory (EMBL) in Grenoble, France. Dr. Belrhali is responsible for in-house crystallography at EMBL/Grenoble and co-responsible of the BM14 beamline for protein crystallography at the ESRF, right next door. |
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Understanding the customers’ needs and how to adapt the x‑ray optics to real life working conditions in a protein crystallography laboratory is key expertise for Xenocs. Together with the expertise of Dr. Belrhali we were able to test different x‑ray optics in a series of experiments over the last six months. As a result of these experiments we could produce outstanding crystallography data with our standard product FOX2D CU 12_38P. The set-up we used was a M18XHF-SRA rotating copper (Cu) anode with a 300 m filament together with our FOX2D optics. As test crystal we decided for elastase, a well known protein, which widely finds its application in protein crystallography testing.
Having a look at the most interesting figures from a protein crystallographer’s point of view, like Rsym and I/ σ, it is not necessary to add long explanations ‑ the outstanding values speak for themselves (cf. image).
For the FOX2D we find about two times more intensity (cts/s/mm˛) in the diffracted peaks compared to competing optics. While most x‑ray optics rather rely on a double reflection by two multilayer mirrors to focus x-rays down to a tiny spot, FOX2D uses only a single reflection to do the same job. This is possible since the FOX2D is based on a single multilayer, which is deposited onto a substrate with a concavely shaped surface in two directions. This unique feature differentiates FOX2D from other x‑ray optics used in laboratory protein crystallography and easily explains the gain in intensity by a factor of two. |
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 03/03/2008 - NEW DISTRIBUTOR IN THE USA
23/03/2007 - GeniX successfully tested at Marresearch for protein crystallography
30/10/2006 - XENOCS receives ISO 9001 certification
16/06/2006 - GeniX beam delivery system
09/03/2006 - Decreasing the size of analysed crystals with FOX2D CU 25_25P
27/09/2005 - FOX2D CU 25_25P a new tool for small crystals
15/06/2005 - FOX2D optics on a synchrotron beamline
01/03/2004 - Protein Crystallography at EMBL test site
01/11/2003 - Space research : ESA signs a contract with XENOCS
01/10/2003 - The Scripps Research Institute boosts its screening capacities
17/03/2003 - Xenocs installs its new confocal optics at EMBL in Heidelberg
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