Protein Crystallography

Protein Crystallography refers to x-ray diffraction analysis of single crystals of organic molecules such as proteins, viruses, or protein complexes. This fast and accurate technique allows the determination of 3D molecular structure at near atomic resolution. It enables the study of molecular interactions which is a critical capability in fields such as rational drug design.

Xenocs extended experience

Xenocs has been dedicated for many years in the development of advanced solutions for protein crystallography allowing the collection of high resolution data sets in the laboratory.

FOX3D product line: advanced optics for protein crystallography

Xenocs FOX3D optics, have been designed to enable challenging applications such as large membrane protein crystal analysis at high throughput, and also to succeed in screening tiny or very weekly diffracting samples, all the while being capable of analyzing long-unit cell crystals. Xenocs FOX3D optics are the most cost effective solutions for significantly improving the throughput and resolution of laboratory x-ray installations, and lead to higher useful flux and better merging statistics (I/σ, Rsym).

GeniX3D product line: a simple solution for high performance inlab protein crystallography

GeniX 3D represents a further step in advanced x-ray beam delivery systems for home lab protein crystallography. Based on a micro focused sealed source, GeniX 3D outperforms traditional Rotating Anode Generators (RAG) in particular for small crystal analysis. With its high level of performance, GeniX 3D is narrowing the gap with modern micro focus rotating anode generators in a low maintenance system. GeniX 3D is available in both Copper and Chromium versions and is adapted to every diffractometer set-up to match your requirements.

Customer feedback

Please have a look at the application notes below to learn more through customer testimonials about the performance of our products for specific applications.

Protein crystallography

File	Title
	Comparison of a conventional rotating anode generator with a Xenocs GeniX micro-beam generator [01/2007]
	The evolution of low-power X-ray beam delivery systems for Macromolecular Crystallography [07/2010]
	Sulphur-SAD phasing of hen egg lysozime with Cu radiation obtained in-house with a Xenocs GeniX micro-beam generator [01/2007]
	Protein crystallography with the GeniX CU High Flux beam delivery system [03/2007]
	High-throughput Sulphur-SAD phasing of Elastase with a STOE-IPDS2T diffractometer and a XENOCS GeniX Cu High Flux beam delivery system [12/2006]
	Comparative testing of FOX3D and FOX2D optics for protein crystallography on a 70 µm rotating anode generator [04/2008]
	Comparison of Helios and Xenocs FOX2D CU25_25P mirrors on a Bruker-AXS MicroStar [11/2007]
	Protein crystal analysis: working with smaller crystals [02/2006]