Structural biology

Optimize protein crystallization conditions. Monitor protein behavior in vitro. Identify systems for drug delivery.

Characterization at the nanoscale can help you find answers.

With X-ray scattering in your lab, you can for example:

  • Study the interactions between proteins (higher order structure), including stability and aggregation pathways
  • Determine protein size, molecular weight and degree of folding
  • Analyze the formation and structure of liquid crystals in lipid drug delivery systems
  • Access the structure of intrinsically disordered proteins and RNA and quantify movements of flexible domains

In-lab SEC-SAXS for structural investigation of complex samples

In this application example, SAXS data of sufficiently high quality to extract structural information such as 3D envelopes of small and large protein species are obtained through in-line gel filtration.

SAXS is ideally suited for analysis of proteins in solution

Molecular weight, degree of folding, radius of gyration, aggregation, size and shape…
What do you want to measure?

Some of our customers

using X-ray scattering for their research in structural biology

Publications

Discover how scientists use Xenocs instruments for their research & publications

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
Parra-Ortiz, E.; Browning, K.L.; Damgaard, L. S. E.; Nordström, R.; Micciulla, S.; Bucciarelli, S.; Malmsten, M.
Journal of Colloid and Interface Science2019
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences2017

Products

Discover our products relevant to research in structural biology.

Nano-inXider

Smart nanoscale characterization

Xeuss 3.0

The Next Generation

(GI-)SAXS/WAXS/USAXS beamline for the laboratory

BioXolver

Accelerate your biostructural research

Services

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Accessories

A wide range of accessories are available for your research.

XSACT software

X-ray Scattering Analysis and Calculation Tool.

Protein Structure Analysis

Protein Structure Analysis

Protein Structure Analysis – Get Shape & Dynamics In Solution In the Lab

Protein Structure Analysis – Get Shape & Dynamics In Solution In the Lab. Measure Your Protein In Its Natural Environment For Formulation And Research